A traditional notion of the discipline of architecture is being disrupted with the advent and implementation of new digital technologies and tools, often adopted from different scientific or industrial disciplines. At the same time, built environments of the 21st century are facing unprecedented challenges at many levels, where scientific understanding of wider environmental conditions and resources is necessary to appropriately address these. By implementing processes-driven design methods and integrating behavioural modelling strategies, an architects’ repertoire to propose habitable and liveable environments will be enhanced, following the aspects of wider cultural and environmental sustainability. Architecture communicates and exchanges information and resources with its adjacent environments, as similar as living organisms with their habitats and other species, creating complex metabolism leading to unique and emergent spatial and temporal living ecologies. By taking a systemic approach to design a system of processes discovered in the living environments into a logic of architectural and urban design, architects and experts of the 21st century will be able to respond to environmental challenges more rigorously and comprehensively where digital technology is intrinsically intertwined with scientific exploration and architects’ creative capacities.